• She looked at the ruins of her home in despair.
• He gave up the search in despair after hours of looking.
• There is still hope; don’t fall into despair.
• The team’s repeated failures led to a sense of despair among the players.
• In his darkest hour, he cried out in despair.
• Despite the despair she felt, she kept moving forward.
• The news filled her with despair, but she refused to lose faith.